Poison

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Poison is a recurring Status Ailment in the Megami Tensei franchise.

Profile

Poison typically inflicts a small-to-moderate amount of damage per turn to those inflicted. In some games, it may also persist after battle, dealing damage every few steps the protagonist takes in the overworld or in a dungeon.

Gameplay

Shin Megami Tensei

Cause
Item —
Skill Toxic Sting, Venom Bite, Venom Breath, Venom Claw
Weapon
Cure
Item Dis-Poison
Skill Posumudi

Shin Megami Tensei II

Shin Megami Tensei if...

Shin Megami Tensei III: Nocturne

Shin Megami Tensei: Strange Journey

Shin Megami Tensei IV

Cause
Item Poison Gas
Skill Poison Claw, Blight, Toxic Sting, Damnation, Poisma, Poison Breath, Shivering Taboo, Lamentation, Ancient Curse
Weapon Pixie Knife, Cursed Muramasa, Poison Glaive, Toxic Rounds, Venom Rounds, Plutonium Rounds
Cure
Item Detox Solution, Dis-Poison, Amrita Soda, Amrita Shower
Skill Posumudi, Amrita, Salvation
Prevention
Skill Null Nerve
Equipment Sturdy Earring, Antidote Ring

Shin Megami Tensei IV: Apocalypse

Shin Megami Tensei V

Shin Megami Tensei V: Vengeance

Poison damage is calculated as follows[1]:

One of two formulas are used to determine a Root value, depending on the attacker's current level. If their level is 150 or below, then Root=⌊Lv+5⌋, where ⌊x⌋ is the floor function. Otherwise, Root=⌊Lv10+140⌋. Difficulty modifiers are applied to Root at this point.

Then, two random numbers, A and B, are used to determine damage variance, with the restrictions of 0≤A≤⌊Root10−1⌋ and 0≤B≤3. Both A and B and added to Root. Finally, Poison Adept and Poison Master are applied, multiplying the final damage; both skills are additive to each other, for a total multiplier of 5.

Last Bible Special

HP will gradually decrease with every step on the field and following every turn in battle. On the field, each step reduces HP by 13.

Cause
Item —
Skill Poison
Weapon —
Cure
Item Antidotal Herb
Skill Poisdi, Dimar, Recarmdra

Persona 3

In Persona 3, a target inflicted with poison will take damage each turn.

Cause
Item —
Skill Poison ArrowPersona 3 FES
Persona 3 Portable
Persona 3 Reload
, Poisma, Poison Mist, Virus Breath, Poison Boost
Weapon Poison Glaive, DeathbringerPersona 3
Persona 3 FES
Persona 3 Portable
, Blood BaghnakhPersona 3
Persona 3 FES
Persona 3 Portable
, RailgunPersona 3
Persona 3 FES
Persona 3 Portable
, Silver MoonPersona 3
Persona 3 FES
Persona 3 Portable
, Malice MaryPersona 3 Reload
, Envenomed BladePersona 3 Reload
, Poison Arrow BowPersona 3 Reload
, OrochitoPersona 3 Reload
, ErinysPersona 3 Reload
, Five-Barrel MedusaPersona 3 Reload
, Poison GlaivePersona 3 Reload
Cure
Item Dis-Poison, Amrita WaterPersona 3 FES
, Baisudi GemPersona 3 Reload
, Mabaisudi GemPersona 3 Reload
, Amrita GemPersona 3 Reload
, Amrita SodaPersona 3 Reload
,Vitae GoldPersona 3 Reload
, Vitae G BottlePersona 3 Reload
, Nutritious AmronionPersona 3 Reload
, Nourishing AmronionPersona 3 Reload
, Doctor in JellyPersona 3 Reload
Skill PosumudiPersona 3
Persona 3 FES
Persona 3 Portable
, BaisudiPersona 3 Reload
, MabaisudiPersona 3 Reload
, AmritaPersona 3
Persona 3 FES
Persona 3 Portable
, Amrita DropPersona 3 Reload
, Amrita ShowerPersona 3 Reload
, Salvation
Prevention
Skill Resist Poison, Null Poison
Equipment Tome of the VoidPersona 3
Persona 3 FES
Persona 3 Portable
, AlicornPersona 3
Persona 3 FES
Persona 3 Portable
, Immunity CharmPersona 3 Reload
, Health SandalsPersona 3 Reload
, Zircaloy LegsPersona 3 Reload
, Amritite NecklacePersona 3 Reload
, Victory HeadbandPersona 3 Reload
, Sanative SandalwoodPersona 3 Reload
, Incense BoxPersona 3 Reload

Persona 4

In Persona 4, a target inflicted with Poison loses HP every time they act, and both their physical and magical damage is halved.

In Golden, a target inflicted with Poison loses HP every time they act, and only their physical damage is halved.

In both games, the effect lasts until it is removed or until after battle.

Cause
Item —
Skill Blight, Poisma, Poison Arrow, Poison Boost, Poison Mist, Poison Skewer, Virus Wave
Weapon Poison Claw, Poison Kunai, Pure Assassin, PinwheelPersona 4 Golden only
Cure
Item Amrita Soda, Dokudami Tea, Hiranya, Hiranya CabbagePersona 4 Golden only
Skill Amrita, Salvation, Posumudi
Prevention
Skill Null Poison, Resist Poison
Equipment Disinfectant, Gas Mask, Kotodama Cape

Persona 4 Arena Ultimax

When a target is Poisoned, they lose HP over time. Poison clears after hitting an opponent, or after a set amount of time.

Digital Devil Saga: Avatar Tuner

Poison persists after battle until it is cured or Solar Noise changes to MIN.

Cause
Item Muscle Drink, Odd Morsel
Skill Foul Breath, Poison Dart, Venom Claw, Venom Fang
Weapon Neutron Shot
Cure
Item Dis-Poison
Skill Posumudi, Salvation, Seraph Grace
Prevention
Skill Void Poison, Repel Magic, Null Poison, Null Ailment, Null Attack
Equipment —

Digital Devil Saga: Avatar Tuner 2

Cause
Item Muscle Drink, Odd Morsel
Skill Foul Breath, Poison Mist, Poison Rain, Venom Claw, Venom Fang, FirePoison version
Weapon Neutron Shot
Cure
Item Dis-Poison
Skill Posumudi, Salvation, Seraph Grace, Call Seraph
Prevention
Skill Void Poison, Void Ailment, Repel Magic, Null Poison, Null Ailment
Equipment Master Ring

Nomenclature

This nomenclature section is a stub. You can help Megami Tensei Wiki by expanding it.
Reason: Missing names.
Names in Other Languages
Language Name Meaning
English Poison
Japanese 毒 Doku Poison
POISON
猛毒Digital Devil Saga series
Mōdoku
Deadly poison

Gallery

References

General
Specific
  1. ↑ CTOBN, Combat Calculation in Shin Megami Tensei V: Vengeance. Published July 10th, 2025. Retrieved September 12, 2025. Steam Community.